CASP1 monoclonal antibody, clone SB122a1
产品名称： CASP1 monoclonal antibody, clone SB122a1
英文名称： CASP1 monoclonal antibody, clone SB122a1
产品编号： MAB8214
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Rat monoclonal antibody raised against native CASP1.
- Immunogen:
- Native purified human CASP1.
- Host:
- Rat
- Reactivity:
- Human
- Form:
- Liquid
- Isotype:
- IgG2a
- Storage Buffer:
- In 100 mM BBS, pH 8.0
- Storage Instruction:
- Store at 4°C.
- Recommend Usage:
- Western Blot (1-5 ug/mL)
The optimal working dilution should be determined by the end user.
- Publication Reference
- 1.
- The enigma of caspase-2: the laymen's view.
Krumschnabel G, Sohm B, Bock F, Manzl C, Villunger A.Cell Death Differ. 2009 Feb;16(2):195-207. Epub 2008 Nov 21.
- 2.
- The caspase-1 digestome identifies the glycolysis pathway as a target during infection and septic shock.
Shao W, Yeretssian G, Doiron K, Hussain SN, Saleh M.J Biol Chem. 2007 Dec 14;282(50):36321-9. Epub 2007 Oct 24.
- 3.
- Caspase-1 activates nuclear factor of the kappa-enhancer in B cells independently of its enzymatic activity.
Lamkanfi M, Kalai M, Saelens X, Declercq W, Vandenabeele P.J Biol Chem. 2004 Jun 4;279(23):24785-93. Epub 2004 Mar 23.
- Entrez GeneID:
- 834
- Gene Name:
- CASP1
- Gene Alias:
- ICE,IL1BC,P45
- Gene Description:
- caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)
- Omim ID:
- 147678
- Gene Ontology:
- Hyperlink
- Gene Summary:
- This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. This gene was identified by its ability to proteolytically cleave and activate the inactive precursor of interleukin-1, a cytokine involved in the processes such as inflammation, septic shock, and wound healing. This gene has been shown to induce cell apoptosis and may function in various developmental stages. Studies of a similar gene in mouse suggest a role in the pathogenesis of Huntington disease. Alternative splicing of this gene results in five transcript variants encoding distinct isoforms. [provided by RefSeq
- Other Designations:
- CASP1 nirs variant 1,IL1B-convertase,caspase 1,caspase 1, apoptosis-related cysteine protease (interleukin 1, beta, convertase),interleukin 1-B converting enzyme,interleukin 1-beta convertase
- Gene Pathway
- Related Disease
- Adenocarcinoma
- Alzheimer Disease
- Asthma
- Asthma
- Bronchiolitis, Viral
- Cardiovascular Diseases
- Cognition
- Coronary Artery Disease
- Diabetes Mellitus, Type 2
- Disease Susceptibility
- Edema
- Gastrointestinal Stromal Tumors
- Genetic Predisposition to Disease
- Hematologic Diseases
- Hodgkin Disease
- Infant, Premature, Diseases
- Inflammation
- Leukemia, chronic myeloid
- Leukemia, Myelogenous, Chronic, BCR-ABL Positive